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ACTH (1-24)

Pituitary Hormone Fragment

Also known as: Cosyntropin · Synacthen · Tetracosactide

The synthetic N-terminal 24-amino-acid fragment of ACTH, retaining full adrenocortical stimulating activity. FDA approved for the Synacthen (cortisol stimulation) diagnostic test.

Typical Dose

250 mcg IV or IM (standard Synacthen test); 1 mcg (low-dose test)

Route

Intravenous or intramuscular

Cycle

Single dose diagnostic

Half-life

~15 minutes

Storage

2–8°C.

ⓘ

Insights on this page are consolidated from peer-reviewed literature and aggregated research data. They do not constitute medical advice. Consult a qualified healthcare professional before use.

Overview

ACTH(1-24), also known as cosyntropin or tetracosactide, is a synthetic peptide comprising the first 24 amino acids of adrenocorticotropic hormone. It retains the full biological activity of native ACTH(1-39) for adrenal cortisol stimulation while being easier to manufacture & having reduced immunogenicity. The Synacthen test (250 mcg IV) is the standard diagnostic for adrenal insufficiency.

Research Indications

Adrenal insufficiency diagnosis

Most Effective

Standard diagnostic: cortisol peak >18–20 mcg/dL at 30–60 min rules out primary adrenal insufficiency.

Inflammatory conditions (depot, Europe)

Effective

Synacthen Depot (long-acting) used in some countries for multiple sclerosis relapses, nephrotic syndrome.

Side Effects & Safety

Common

  • Flushing
  • Rash at injection site

Uncommon

  • Anaphylaxis (rare)

When to Stop

  • Known hypersensitivity to cosyntropin

How to Reconstitute

1

Commercial product for diagnostic use.

Dosing math: Clinical use only.

Quality Indicators

Good — use as normal

  • Per manufacturer

Discard immediately

  • Per manufacturer

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-QTOF-MS & HPLC analysis with a signed analytical report.

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