Alpha-MSH
Endogenous MelanocortinAlso known as: Alpha-Melanocyte-Stimulating Hormone · α-MSH
The natural 13-amino-acid melanocortin peptide produced by the pituitary. Acts on MC1-5 receptors with broad effects on pigmentation, inflammation, appetite, & thermoregulation.
Typical Dose
Research standard; practically replaced by analogs
Route
Intravenous (research); intranasal (some protocols)
Cycle
N/A for practical use
Half-life
~3–4 minutes
Storage
Lyophilized: 2–8°C. Reconstituted: use immediately.
Overview
Alpha-MSH is an endogenous peptide derived from proopiomelanocortin (POMC) cleavage in the pituitary & skin. It is the natural ligand for melanocortin receptors 1 through 5 & serves as the biological reference point for all synthetic melanocortin analogs (Melanotan II, PT-141, Setmelanotide).
Its very short half-life (~3–4 minutes) makes native alpha-MSH impractical for injection-based use — it is degraded almost immediately in circulation. Research use typically involves it as a reference compound. Synthetic analogs with extended half-lives are used for all clinical applications.
Quick Start Guide
Alpha-MSH has a ~3 min half-life. Practical administration requires analogs (Melanotan II, PT-141). Used in research as a reference standard.
Research Indications
Melanogenesis (reference)
Research OnlyEndogenous MC1R agonist. Reference compound for all synthetic tanning peptides.
Anti-inflammatory (systemic)
Research OnlyInhibits NF-kB & pro-inflammatory cytokines via MC1R & MC3R on immune cells. Studied for inflammation without immunosuppression.
Peptide Interactions
Melanotan II is a synthetic analog of alpha-MSH with extended half-life.
Side Effects & Safety
Common
- Flushing (intranasal/IV administration)
Uncommon
- Nausea
When to Stop
- Signs of allergic reaction
How to Reconstitute
Use immediately after reconstitution given very short stability at physiological conditions.
Dosing math: Not typically used for subcutaneous injection; see Melanotan II or PT-141 for practical analogs.
Quality Indicators
Good — use as normal
- Clear, colorless solution
Discard immediately
- Any discoloration or particulate
Community Insights
Self-reported. Reflects user experience, not clinical outcomes.
Verify what you have
Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.
Submit a sample