← Compound Library

Beta-Endorphin

Endogenous Opioid Peptide

Also known as: β-Endorphin · Beta-LPH(61-91)

The primary endogenous opioid peptide (31 amino acids) produced from POMC cleavage. Binds mu-, delta-, & kappa-opioid receptors with high affinity. Central mediator of pain, reward, & stress analgesia.

Typical Dose

Research standard — not applicable for clinical/self-use

Route

Intracerebroventricular or IV (research only)

Cycle

N/A

Half-life

~90 minutes in plasma

Storage

Lyophilized: −20°C for long-term storage. 2–8°C short-term.

Overview

Beta-Endorphin is a 31-amino-acid opioid peptide derived from pro-opiomelanocortin (POMC) cleavage in the pituitary & hypothalamus. It is the most potent endogenous opioid, with approximately 18–33x the analgesic potency of morphine. It acts primarily on mu-opioid receptors (analgesia, reward, euphoria) & mediates the analgesic & mood-elevating effects of exercise, laughter, & social bonding. Research use is primarily as a reference compound.

Quick Start Guide

1

Not used for therapeutic injection. Research reference compound only.

Research Indications

Stress analgesia (endogenous reference)

Research Only

Central mediator of stress-induced analgesia & exercise-induced euphoria ('runner's high').

Side Effects & Safety

Common

  • Mu-opioid effects at high doses: sedation, respiratory depression (research risk)

When to Stop

  • Signs of opioid toxicity

How to Reconstitute

1

Research reconstitution per protocol.

Dosing math: Research use only.

Quality Indicators

Good — use as normal

  • Clear solution

Discard immediately

  • Particulate

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

Submit a sample