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CRH

Hypothalamic Hormone

Also known as: Corticotropin-Releasing Hormone · CRF · Corticoiberin

The hypothalamic 41-amino-acid neuropeptide that drives ACTH release from the pituitary, initiating the stress response axis. Research tool for HPA axis assessment.

Typical Dose

1 mcg/kg IV (diagnostic CRH stimulation test)

Route

Intravenous (diagnostic)

Cycle

Single dose diagnostic

Half-life

~7–10 minutes

Storage

2–8°C.

Overview

CRH is the key hypothalamic regulator of the HPA axis, stimulating anterior pituitary corticotrophs to release ACTH, which then drives adrenal cortisol production. Clinically, ovine CRH (corticorelin) is used as a diagnostic test for Cushing's syndrome (to distinguish pituitary vs. ectopic ACTH). Research interest focuses on CRH antagonists for anxiety & depression.

Quick Start Guide

1

Diagnostic use only (CRH stimulation test). 1 mcg/kg IV bolus.

Research Indications

HPA axis diagnostic testing

Most Effective

Corticorelin (ovine CRH) FDA approved for differentiating Cushing's disease from ectopic ACTH.

Side Effects & Safety

Common

  • Flushing
  • Metallic taste
  • Tachycardia (brief)

Uncommon

  • Hypotension
  • Dyspnea

When to Stop

  • Cardiovascular instability

How to Reconstitute

1

Diagnostic product — clinical use only.

Dosing math: Clinical product.

Quality Indicators

Good — use as normal

  • Per manufacturer

Discard immediately

  • Per manufacturer

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

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