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Dermorphin

Exogenous Opioid Peptide (Amphibian)

Also known as: YAFGYPS-amide

A 7-amino-acid frog-skin heptapeptide with exceptionally potent mu-opioid receptor activity — 30–40x more potent than morphine. Banned in equine sport for illicit analgesic use.

Typical Dose

Research standard

Route

Intrathecal or IV (research)

Cycle

N/A

Half-life

Hours (D-amino acid stability)

Storage

Lyophilized: −20°C.

Overview

Dermorphin is a heptapeptide from Phyllomedusa sauvagei frog skin containing a D-alanine residue that confers resistance to enzymatic degradation & extremely high mu-opioid receptor affinity. It is 30–40x more potent than morphine by injection. WADA & equine sport governing bodies ban it as a performance-enhancing analgesic in horses. It is a research reference compound & is illegal for use in equine competition.

Quick Start Guide

1

Research reference compound only. Illegal for equine athletic use.

Research Indications

Mu-opioid receptor research

Research Only

Exceptionally potent MOR agonist. Reference compound for high-affinity opioid binding studies.

Side Effects & Safety

When to Stop

  • Signs of opioid toxicity

How to Reconstitute

1

Research use only.

Dosing math: Research only.

Quality Indicators

Good — use as normal

  • Clear solution

Discard immediately

  • Particulate

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

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