DSIP
Sleep / Neuromodulator PeptideAlso known as: Delta Sleep-Inducing Peptide · DSIP nonapeptide
A nonapeptide isolated from rabbit brain that induces delta sleep, modulates stress hormones, & has shown anti-stress & analgesic properties.
Typical Dose
200–500 mcg pre-sleep
Route
Subcutaneous injection
Cycle
2–4 weeks
Half-life
~30 minutes (nonapeptide; rapidly degraded)
Storage
Reconstituted: 2–8°C, use within 30 days.
Overview
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from rabbit brain in 1974 & named for its ability to induce slow-wave (delta) sleep when administered to animals. It is widely distributed in the CNS & peripheral tissues & likely functions as a neuromodulator rather than a neurotransmitter.
Clinical effects in humans include reduction of sleep-onset latency, normalization of sleep architecture, & analgesic properties independent of opioid receptors. Some researchers have studied it for alcohol withdrawal, pain syndromes, & stress-related disorders. Its mechanism remains incompletely understood.
Quick Start Guide
Reconstitute with 1 mL BAC water per 5 mg vial.
Inject 200–500 mcg subcutaneously 30–60 minutes before sleep.
Research Indications
Sleep quality improvement
EffectiveInduces delta (slow-wave) sleep in animals. Human studies show improved sleep architecture & sleep onset.
Stress modulation
ModerateReduces hypothalamo-pituitary-adrenal axis activation in stressed animals. Some human data on stress reduction.
Research Protocols
Sleep improvement
2–4 weeksDose
200–300 mcg
Frequency
30–60 min before sleep
Route
SubQ abdomen
Peptide Interactions
Both target sleep quality & circadian regulation through different mechanisms. Sometimes combined.
Side Effects & Safety
Common
- Drowsiness (intended effect)
- Injection site redness
Uncommon
- Headache on waking
- Vivid dreams
When to Stop
- Signs of allergic reaction
How to Reconstitute
Wipe stopper. Add 1 mL BAC water. Swirl gently. Refrigerate.
Dosing math: 1 mL BAC water per 5 mg = 5000 mcg/mL. For 300 mcg: 0.06 mL.
Quality Indicators
Good — use as normal
- Clear, colorless solution
Acceptable
- Very faint tint
Discard immediately
- Cloudiness
- Particulate
What to Expect
Week 1
Sleep onset improvements typically noticeable within the first few doses.
Week 2–4
Consistent delta sleep promotion & stress reduction accumulating.
Community Insights
Self-reported. Reflects user experience, not clinical outcomes.
Research References
The delta sleep-inducing peptide (DSIP): a review
Journal of Neuroscience Research · 1990
Comprehensive review of DSIP isolation, neurochemistry, sleep-inducing properties, & clinical applications.
Verify what you have
Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.
Submit a sample