DSIP
Sleep / Neuromodulator PeptideAlso known as: Delta Sleep-Inducing Peptide · DSIP nonapeptide
A nonapeptide isolated from rabbit brain that induces delta sleep, modulates stress hormones, & has shown anti-stress & analgesic properties.
Typical Dose
200–500 mcg pre-sleep
Route
Subcutaneous injection
Cycle
2–4 weeks
Half-life
~30 minutes (nonapeptide; rapidly degraded)
Storage
Reconstituted: 2–8°C, use within 30 days.
Insights on this page are consolidated from peer-reviewed literature and aggregated research data. They do not constitute medical advice. Consult a qualified healthcare professional before use.
Overview
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from rabbit brain in 1974 & named for its ability to induce slow-wave (delta) sleep when administered to animals. It is widely distributed in the CNS & peripheral tissues & likely functions as a neuromodulator rather than a neurotransmitter.
Clinical effects in humans include reduction of sleep-onset latency, normalization of sleep architecture, & analgesic properties independent of opioid receptors. Some researchers have studied it for alcohol withdrawal, pain syndromes, & stress-related disorders. Its mechanism remains incompletely understood.
Research Indications
Sleep quality improvement
EffectiveInduces delta (slow-wave) sleep in animals. Human studies show improved sleep architecture & sleep onset.
Stress modulation
ModerateReduces hypothalamo-pituitary-adrenal axis activation in stressed animals. Some human data on stress reduction.
Research References
The delta sleep-inducing peptide (DSIP): a review
Journal of Neuroscience Research · 1990
Comprehensive review of DSIP isolation, neurochemistry, sleep-inducing properties, & clinical applications.
Research Protocols
Sleep improvement
2–4 weeksDose
200–300 mcg
Frequency
30–60 min before sleep
Route
SubQ abdomen
Peptide Interactions
Both target sleep quality & circadian regulation through different mechanisms. Sometimes combined.
Side Effects & Safety
Common
- Drowsiness (intended effect)
- Injection site redness
Uncommon
- Headache on waking
- Vivid dreams
When to Stop
- Signs of allergic reaction
How to Reconstitute
Wipe stopper. Add 1 mL BAC water. Swirl gently. Refrigerate.
Dosing math: 1 mL BAC water per 5 mg = 5000 mcg/mL. For 300 mcg: 0.06 mL.
Quality Indicators
Good — use as normal
- Clear, colorless solution
Acceptable
- Very faint tint
Discard immediately
- Cloudiness
- Particulate
What to Expect
Week 1
Sleep onset improvements typically noticeable within the first few doses.
Week 2–4
Consistent delta sleep promotion & stress reduction accumulating.
Community Insights
Self-reported. Reflects user experience, not clinical outcomes.
Verify what you have
Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-QTOF-MS & HPLC analysis with a signed analytical report.
Submit a sample