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Dynorphin A (1-13)

Endogenous Opioid Peptide

Also known as: Dyn A(1-13) · YGGFLRRIRPKLK

A 13-amino-acid kappa-opioid receptor agonist & the predominant endogenous kappa ligand. Associated with stress-induced dysphoria, pain, & appetite regulation.

Typical Dose

Research standard

Route

Intrathecal or IV (research)

Cycle

N/A

Half-life

Minutes (plasma)

Storage

Lyophilized: −20°C.

Overview

Dynorphin A (1-13) is the N-terminal 13-amino-acid fragment of Dynorphin A that retains full kappa-opioid receptor (KOR) agonist activity. Dynorphin is the primary endogenous KOR agonist & mediates stress-induced dysphoria, aversive states, & pain in the context of chronic stress. KOR antagonists are under active development for depression & addiction. Dynorphin itself is a research tool for KOR pharmacology.

Quick Start Guide

1

Research reference compound only.

Research Indications

Kappa-opioid receptor research

Research Only

Primary endogenous KOR agonist. Standard for KOR pharmacology & stress-dysphoria research.

Side Effects & Safety

When to Stop

  • Signs of opioid toxicity

How to Reconstitute

1

Research reconstitution.

Dosing math: Research use only.

Quality Indicators

Good — use as normal

  • Clear solution

Discard immediately

  • Particulate

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

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