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Endomorphin-1

Endogenous Opioid Peptide

Also known as: YPWF-NH2

A tetrapeptide with the highest selectivity & affinity for the mu-opioid receptor of any known endogenous opioid. Research tool for understanding mu-receptor-mediated analgesia.

Typical Dose

Research standard

Route

Intrathecal or IV (research)

Cycle

N/A

Half-life

<1 minute in plasma

Storage

Lyophilized: −20°C.

Overview

Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) was identified in 1997 as the most selective & potent endogenous mu-opioid receptor agonist known. It produces analgesia, hypothermia, & catalepsy in animal models. Unlike beta-endorphin, it lacks significant delta-opioid activity. Stable analogs are under development for pain management. Not for clinical or research self-administration.

Quick Start Guide

1

Research reference compound only.

Research Indications

Mu-opioid receptor research

Research Only

Highest selectivity endogenous MOR agonist. Standard research tool.

Side Effects & Safety

When to Stop

  • Signs of opioid toxicity

How to Reconstitute

1

Research reconstitution.

Dosing math: Research use only.

Quality Indicators

Good — use as normal

  • Clear solution

Discard immediately

  • Particulate

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

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