← Compound Library

Endomorphin-2

Endogenous Opioid Peptide

Also known as: YPFF-NH2

The second endomorphin tetrapeptide with high mu-opioid receptor selectivity & potent spinal analgesia. Complement to Endomorphin-1 with distinct CNS distribution.

Typical Dose

Research standard

Route

Intrathecal or IV (research)

Cycle

N/A

Half-life

<1 minute

Storage

Lyophilized: −20°C.

Overview

Endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) was identified alongside Endomorphin-1 as a high-affinity mu-opioid receptor agonist. It predominates in the spinal cord (versus Endomorphin-1's supraspinal distribution), making it particularly relevant to spinal pain modulation. Research interest in its stable analogs as non-addictive opioid alternatives is ongoing.

Quick Start Guide

1

Research reference compound only.

Research Indications

Mu-opioid receptor / spinal analgesia research

Research Only

Spinal MOR agonism; reference for analgesic research.

Side Effects & Safety

When to Stop

  • Signs of opioid toxicity

How to Reconstitute

1

Research use.

Dosing math: Research only.

Quality Indicators

Good — use as normal

  • Clear solution

Discard immediately

  • Particulate

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

Submit a sample