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Ganirelix

GnRH Antagonist

Also known as: Orgalutran · Antagon

A synthetic decapeptide GnRH antagonist used in IVF to prevent premature LH surges, providing an alternative to GnRH agonist down-regulation protocols.

Typical Dose

0.25 mg once daily SubQ

Route

Subcutaneous injection

Cycle

4–6 days within IVF cycle

Half-life

~13 hours

Storage

Room temperature or 2–8°C per manufacturer.

Overview

Ganirelix is a synthetic GnRH antagonist used in controlled ovarian stimulation (COS) for IVF. Like cetrorelix, it immediately suppresses LH without an initial surge, allowing for shorter & more flexible IVF stimulation protocols.

Quick Start Guide

1

Clinical use only. 0.25 mg SubQ daily starting on stimulation day 6.

Research Indications

IVF premature LH surge prevention

Most Effective

FDA approved. Prevents premature luteinization during COS. Equivalent efficacy to cetrorelix.

Research Protocols

IVF LH suppression

Until HCG trigger

Dose

0.25 mg once daily

Frequency

Daily from stimulation day 6

Route

SubQ

Side Effects & Safety

Common

  • Injection site reactions
  • Headache
  • Abdominal pain

Uncommon

  • OHSS
  • Nausea

When to Stop

  • OHSS signs
  • Signs of allergic reaction

How to Reconstitute

1

Pre-filled syringe — no reconstitution.

Dosing math: Commercial pre-filled syringe.

Quality Indicators

Good — use as normal

  • Per manufacturer

Discard immediately

  • Particulate or discoloration

What to Expect

Day 1–6

Immediate LH suppression. Follicular development continues under FSH stimulation.

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

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