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GHRP-2

GH Secretagogue (GHS-R1a agonist)

Also known as: KP-102 · Growth Hormone-Releasing Peptide-2

A potent hexapeptide GH secretagogue with strong pulse output & moderate cortisol/prolactin elevation. Preferred over GHRP-6 when appetite stimulation is undesirable.

Typical Dose

100–200 mcg per injection, 1–3x daily

Route

Subcutaneous injection

Cycle

12–24 weeks

Half-life

~30 minutes

Storage

Lyophilized: room temp or freezer. Reconstituted: 2–8°C, use within 30 days.

Overview

GHRP-2 is a synthetic hexapeptide that acts on the GHS-R1a (ghrelin) receptor to stimulate pulsatile GH release from the anterior pituitary. It produces higher GH output than Ipamorelin but at the cost of moderate cortisol & prolactin elevation, particularly at doses above 100 mcg.

Unlike GHRP-6, GHRP-2 does not strongly stimulate appetite via ghrelin pathways at standard doses, making it a middle ground between the clean profile of Ipamorelin & the aggressive GH output of Hexarelin. It is typically paired with a GHRH analog (CJC-1295, Sermorelin) for synergistic GH release.

Quick Start Guide

1

Reconstitute with 2 mL bacteriostatic water per 2 mg vial (1000 mcg/mL).

2

Inject 100–200 mcg subcutaneously 30 minutes before sleep. Stack with 100 mcg CJC-1295 (no DAC) for full effect.

3

Avoid food for 2 hours before injection; insulin blunts GH release.

Research Indications

GH pulse stimulation

Most Effective

Produces stronger GH pulses than Ipamorelin. Peak serum GH at 15–30 min post-injection.

Body composition & recovery

Effective

Downstream IGF-1 elevation drives lean mass & lipolysis. Similar arc to Ipamorelin but with higher peak GH.

Appetite stimulation

Moderate

Less ghrelin-mediated hunger than GHRP-6 but more than Ipamorelin. Relevant for users in caloric deficit.

Research Protocols

GH pulse (GHRH/GHRP stack)

12–24 weeks

Dose

100 mcg GHRP-2 + 100 mcg CJC-1295 (no DAC)

Frequency

1–3x daily (pre-sleep minimum)

Route

SubQ abdomen

Recovery (with repair peptides)

8–12 weeks alongside BPC-157

Dose

100 mcg

Frequency

2x daily

Route

SubQ abdomen

Peptide Interactions

GHRH + GHRP synergy. GHRP-2 acts on GHS-R1a; CJC-1295 on GHRH receptors. Combined pulse significantly exceeds either alone.

IpamorelinCompatible

Both act on GHS-R1a; stacking two GHRPs offers diminishing returns. Choose one.

BPC-157Synergistic

GH pulse elevates IGF-1, complementing BPC-157's local repair signaling.

Side Effects & Safety

Common

  • Cortisol elevation (especially above 200 mcg/dose)
  • Prolactin elevation
  • Increased hunger
  • Flushing
  • Water retention

Uncommon

  • Headache
  • Tingling in extremities
  • Dizziness

When to Stop

  • Known or suspected malignancy
  • Signs of allergic reaction
  • Diabetics: monitor glucose

How to Reconstitute

1

Wipe stopper with alcohol swab.

2

Draw 2 mL bacteriostatic water into syringe.

3

Inject slowly down inner vial wall. Swirl gently.

4

Refrigerate at 2–8°C. Use within 30 days.

Dosing math: 2 mL BAC water per 2 mg vial = 1000 mcg/mL. For 100 mcg: 0.1 mL. For 200 mcg: 0.2 mL.

Quality Indicators

Good — use as normal

  • Clear, colorless solution

Acceptable

  • Very faint cloudiness that clears immediately on swirl

Discard immediately

  • Persistent cloudiness
  • Particulate
  • Discoloration

What to Expect

Week 1–2

GH pulses begin immediately. Sleep quality often improves first. Cortisol & prolactin elevations are measurable but usually asymptomatic.

Week 3–6

IGF-1 rises. Body composition changes begin. Similar to Ipamorelin timeline but slightly faster onset of muscle fullness due to higher GH peak.

Week 7–16

Sustained improvements in recovery & body composition. Water retention may be more pronounced than with Ipamorelin.

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Research References

GHRP-2 & Ipamorelin: stimulatory effects on growth hormone secretion in humans

Journal of Clinical Endocrinology & Metabolism · 1999

Comparative human study showing dose-dependent GH release with both peptides; GHRP-2 produced higher peak GH.

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Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

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