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Leu-Enkephalin

Endogenous Opioid Peptide

Also known as: Leucine Enkephalin · YGGFL

One of the two endogenous enkephalin pentapeptides, acting primarily on delta-opioid receptors with rapid enzymatic degradation in plasma.

Typical Dose

Research standard

Route

IV or intrathecal (research)

Cycle

N/A

Half-life

<1 minute in plasma

Storage

Lyophilized: −20°C.

Overview

Leu-Enkephalin (Tyr-Gly-Gly-Phe-Leu) is one of two pentapeptide enkephalins (the other being Met-Enkephalin) discovered as endogenous ligands for opioid receptors. It acts primarily on delta-opioid receptors (DOR) & to a lesser degree mu-opioid receptors. Its half-life in plasma is less than 1 minute due to enkephalinase degradation. Primarily a research compound — stable analogs are used for any therapeutic application.

Quick Start Guide

1

Research reference compound only.

Research Indications

Delta-opioid receptor research

Research Only

Standard ligand for DOR characterization.

Side Effects & Safety

When to Stop

  • Signs of opioid toxicity

How to Reconstitute

1

Research use. Reconstitute in aqueous buffer.

Dosing math: Unstable in plasma — use immediately.

Quality Indicators

Good — use as normal

  • Clear solution

Discard immediately

  • Particulate

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

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