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Met-Enkephalin

Endogenous Opioid Peptide / Immune Modulator

Also known as: Methionine Enkephalin · YGGFM · Opioid Growth Factor

The methionine-containing endogenous enkephalin pentapeptide. Acts on delta- & zeta-opioid receptors & also has immunomodulatory & anti-tumor properties as opioid growth factor (OGF).

Typical Dose

Research standard for peptide; LDN modulates endogenous OGF indirectly

Route

IV (research), intrathecal

Cycle

N/A

Half-life

<1 minute in plasma

Storage

Lyophilized: −20°C.

Overview

Met-Enkephalin (Tyr-Gly-Gly-Phe-Met) acts on delta-opioid receptors (pain modulation) & zeta (OGF) receptors where it functions as the Opioid Growth Factor (OGF), regulating cell proliferation. As OGF, met-enkephalin has shown anti-tumor effects in multiple cancer types & is being investigated for autoimmune diseases. Low-dose naltrexone (LDN) works partly by transiently blocking OGF receptors, causing rebound upregulation.

Quick Start Guide

1

Not for injection-based wellness use. Research & OGF receptor applications only.

Research Indications

Anti-tumor (OGF mechanism)

Research Only

Inhibits tumor cell proliferation via OGF/zeta receptor. Human studies in pancreatic & head/neck cancer.

Side Effects & Safety

When to Stop

  • Signs of opioid toxicity

How to Reconstitute

1

Research use.

Dosing math: Research compound — not suitable for clinical self-administration.

Quality Indicators

Good — use as normal

  • Clear solution

Discard immediately

  • Particulate

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

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