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Nafarelin

GnRH Agonist (intranasal)

Also known as: Synarel

A GnRH agonist administered as a nasal spray, approved for endometriosis & central precocious puberty.

Typical Dose

200 mcg/nostril 2x/day (endometriosis); 400 mcg/nostril 2x/day (precocious puberty)

Route

Intranasal spray

Cycle

6 months (endometriosis)

Half-life

~3 hours

Storage

Room temperature, upright.

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Insights on this page are consolidated from peer-reviewed literature and aggregated research data. They do not constitute medical advice. Consult a qualified healthcare professional before use.

Overview

Nafarelin is a GnRH agonist available only as an intranasal spray (Synarel). It is FDA approved for endometriosis & central precocious puberty. The nasal route distinguishes it from most other GnRH agonists that require injection.

Research Indications

Endometriosis

Most Effective

FDA approved. Reduces endometrial lesions & pain via estrogen suppression.

Central precocious puberty

Most Effective

FDA approved. Suppresses premature pubertal progression.

Research Protocols

Endometriosis

6 months

Dose

200 mcg/nostril 2x/day

Frequency

Twice daily

Route

Intranasal

Side Effects & Safety

Common

  • Hot flashes
  • Decreased libido
  • Headache
  • Emotional lability

Uncommon

  • Bone density loss (6-month use)
  • Nasal irritation

When to Stop

  • Osteoporosis risk exceeds benefit
  • Signs of allergic reaction

How to Reconstitute

1

Pre-filled nasal spray — no reconstitution required.

Dosing math: Commercial product only.

Quality Indicators

Good — use as normal

  • Per manufacturer

Discard immediately

  • Discolored or crystallized solution

What to Expect

Week 2–6

Estrogen suppression & symptom reduction begin. Bone mineral density monitoring recommended for 6-month courses.

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-QTOF-MS & HPLC analysis with a signed analytical report.

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