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Nociceptin/Orphanin FQ

Endogenous Opioid-Like Peptide

Also known as: N/OFQ · Orphanin FQ · FGGFTGARKSARKLANQ

The endogenous ligand of the NOP (nociceptin/orphanin FQ) receptor, the fourth opioid receptor family member. Modulates pain, anxiety, stress response, & addiction.

Typical Dose

Research standard

Route

Intrathecal or IV (research)

Cycle

N/A

Half-life

Minutes

Storage

Lyophilized: −20°C.

Overview

Nociceptin/Orphanin FQ (N/OFQ) is a 17-amino-acid peptide that is the endogenous agonist at the NOP receptor (also called ORL1), the fourth member of the opioid receptor superfamily. Despite structural homology to opioids, NOP activation produces distinct & often opposite effects: it inhibits morphine analgesia, modulates anxiety (often anxiolytic at low doses), & reduces stress responses. NOP antagonists & partial agonists are in clinical development for depression, pain, & Parkinson's disease.

Quick Start Guide

1

Research compound only.

Research Indications

NOP receptor research

Research Only

Reference ligand for NOP/ORL1 receptor pharmacology.

How to Reconstitute

1

Research use.

Dosing math: Research only.

Quality Indicators

Good — use as normal

  • Clear solution

Discard immediately

  • Particulate

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

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