Thymalin

Thymic Immune Modulator

Also known as: Thymus polypeptide · Timogen

A polypeptide thymus extract with immunomodulatory & anti-aging properties. Used in Russian & Eastern European medicine for immune reconstitution & longevity.

Typical Dose

5–10 mg once daily for 10 days (2–3 cycles per year)

Route

Intramuscular injection (preferred) or SubQ

Cycle

10-day cycles, 2–3x per year

Half-life

Short (polypeptide mixture; variable)

Storage

Lyophilized: 2–8°C. Reconstituted: use within 24 hours.

Overview

Thymalin is a polypeptide preparation extracted from bovine thymus gland, developed by Professor Vladimir Khavinson (the same researcher behind Epitalon). It contains multiple short peptides derived from thymic stromal proteins & is thought to act through a similar immunomodulatory mechanism to Thymosin Alpha-1.

Clinical use in Russia spans over 30 years for a range of conditions including immune deficiency, chronic infection, cancer adjuvant therapy, & aging-related immune decline. Human longevity studies from St. Petersburg showed significantly lower mortality over 6–8 year follow-up in elderly subjects treated with cyclical Thymalin.

Quick Start Guide

Reconstitute with 1 mL sterile water per 10 mg vial.

Inject 5–10 mg intramuscularly once daily for 10 days. Repeat 2–3 times per year.

Research Indications

Immune reconstitution

Effective

Restores T-cell & NK cell function in age-related or pathology-related immune decline. Russian clinical tradition spans 30+ years.

Anti-aging / longevity

Moderate

Geroprotective studies show reduced mortality in elderly subjects over 6–8 year follow-up with cyclical treatment.

Research Protocols

Immune cycle (standard)

10 consecutive days; repeat 2–3x/year

Dose

5–10 mg

Frequency

Once daily IM

Route

Peptide Interactions

EpitalonCompatible

Khavinson's longevity protocols frequently combine Thymalin (thymus) with Epitalon (pineal). Complementary immune + telomere/circadian effects.

Side Effects & Safety

Common

Injection site soreness (IM injection)
Transient fatigue

Uncommon

Mild fever (immune activation)

When to Stop

Active autoimmune disease
Signs of allergic reaction

How to Reconstitute

Add 1 mL sterile water per 10 mg vial.

Swirl gently until dissolved.

Use within 24 hours.

Dosing math: 1 mL sterile water per 10 mg = 10000 mcg/mL. For 5 mg: 0.5 mL. Use BAC water only if multi-dose across multiple days.

Quality Indicators

Good — use as normal

Clear to slightly opalescent solution (polypeptide mix may be slightly turbid)

Acceptable

Slight turbidity consistent with polypeptide extract nature

Discard immediately

Visible particulate
Strong discoloration
Unrefrigerated reconstituted product

What to Expect

Days 1–10 (active cycle)

Immune activation begins within days. Some users notice improved energy & mood during the cycle.

Post-cycle (weeks–months)

Immune reconstitution effect persists for months after a 10-day cycle. Longevity effects are not experientially measurable.

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Research References

Geroprotective effects of thymus peptides in elderly subjects

Bulletin of Experimental Biology & Medicine · 2003

6–8 year follow-up study showing significantly reduced mortality in elderly subjects treated with cyclical Thymalin.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

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