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TRH

Hypothalamic Hormone

Also known as: Thyrotropin-Releasing Hormone · Protirelin · Relefact TRH

The tripeptide hypothalamic hormone that triggers TSH release from the pituitary. Used diagnostically to assess pituitary thyroid reserve.

Typical Dose

200–500 mcg IV (TRH stimulation test)

Route

Intravenous (diagnostic)

Cycle

Single dose

Half-life

~5 minutes

Storage

Room temperature.

Overview

TRH (pyro-Glu-His-Pro-NH2) is the tripeptide produced by the hypothalamus that stimulates release of TSH (and prolactin) from the anterior pituitary. It is used clinically as the TRH stimulation test to evaluate pituitary thyroid reserve & diagnose certain hypothalamic vs. pituitary thyroid disorders. Research interest in TRH & analogs also extends to neuroprotective & CNS-activating effects.

Quick Start Guide

1

Clinical diagnostic use only. 200–500 mcg IV bolus.

Research Indications

Hypothalamic-pituitary-thyroid axis diagnostic

Most Effective

Standard diagnostic tool for assessing pituitary TSH reserve & differentiating central vs. primary hypothyroidism.

Side Effects & Safety

Common

  • Urge to urinate
  • Metallic taste
  • Nausea
  • Flushing

Uncommon

  • Hypotension (rare)

When to Stop

  • Known pituitary tumor sensitive to TSH stimulation

How to Reconstitute

1

Commercial IV product.

Dosing math: Clinical use only.

Quality Indicators

Good — use as normal

  • Per manufacturer

Discard immediately

  • Per manufacturer

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

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