VIP

Neuropeptide / Vasodilator

Also known as: Vasoactive Intestinal Peptide · VIP 1-28

A 28-amino-acid neuropeptide with broad vasodilatory, anti-inflammatory, & immune-modulatory effects. Studied for pulmonary arterial hypertension & inflammatory disorders.

Typical Dose

50–200 mcg/day

Route

Subcutaneous injection or inhaled (clinical)

Cycle

4–8 weeks

Half-life

~1–2 minutes (rapid plasma degradation)

Storage

Lyophilized: 2–8°C. Reconstituted: use within 24 hours (poor stability).

Overview

VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide produced by neurons throughout the gut, respiratory tract, & CNS. It acts on VPAC1 & VPAC2 receptors to produce vasodilation, bronchodilation, GI motility regulation, immune suppression, & circadian rhythm modulation.

Clinical development has focused on pulmonary arterial hypertension (inhaled VIP showed pulmonary vasodilation in small trials) & inflammatory bowel disease. In research wellness contexts, VIP has attracted interest for its anti-inflammatory, vagal-tone-enhancing, & sleep-regulating properties.

Quick Start Guide

Research protocols vary widely. Common: 50–200 mcg SubQ once daily.

VIP is unstable — use freshly reconstituted solution; do not store reconstituted product more than 24 hours.

Research Indications

Pulmonary arterial hypertension

Research Only

Inhaled VIP reduced pulmonary vascular resistance in small human trials. No approved therapeutic product.

Anti-inflammatory / immune modulation

Moderate

Reduces pro-inflammatory cytokines. Studied in Crohn's disease & RA models.

Research Protocols

Anti-inflammatory research

4–8 weeks

Dose

50–100 mcg SubQ

Frequency

Once daily

Route

SubQ

Use freshly reconstituted solution; VIP degrades rapidly.

Side Effects & Safety

Common

Flushing
Hypotension (vasodilator effect)
Headache

Uncommon

Tachycardia

When to Stop

Symptomatic hypotension
Signs of allergic reaction

How to Reconstitute

Reconstitute with sterile water immediately before use.

VIP degrades rapidly — use within 1–2 hours of reconstitution.

Dosing math: Do not use BAC water for multi-dose storage. VIP is very unstable in aqueous solution.

Quality Indicators

Good — use as normal

Clear, colorless solution immediately after reconstitution

Discard immediately

Any reconstituted solution more than 2–4 hours old

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

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