Semax

Nootropic / BDNF Upregulator

Also known as: MEHFPGP · Synacthen analog

A synthetic heptapeptide ACTH analog developed in Russia with cognitive-enhancing, neuroprotective, & BDNF-upregulating properties. Approved for stroke & cognitive deficit treatment.

Typical Dose

300–600 mcg 1–2x daily

Route

Intranasal (most common) or subcutaneous injection

Cycle

2–4 weeks on, 1–2 weeks off

Half-life

~7 minutes (active peptide); BDNF effects persist for days

Storage

Reconstituted: 2–8°C, use within 30 days.

Overview

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the adrenocorticotropic hormone (ACTH) fragment ACTH(4-10) with added Pro-Gly-Pro for stability. It is approved by the Russian Ministry of Health for treatment of stroke, memory disturbances, & attention deficit disorders.

Its primary mechanisms include upregulation of BDNF (brain-derived neurotrophic factor) & NGF (nerve growth factor) synthesis, potentiation of dopaminergic & serotonergic neurotransmission, & neuroprotective effects against ischemia-reperfusion injury. Unlike stimulants, its cognitive enhancement is mediated through neuroplasticity rather than neurotransmitter depletion.

Quick Start Guide

Reconstitute with 1 mL bacteriostatic water per 5–10 mg vial.

Intranasal: 300–600 mcg (3–6 drops per nostril) once or twice daily.

SubQ: 300 mcg once or twice daily.

Research Indications

Cognitive enhancement

Most Effective

Russian approved for cognitive deficit. BDNF upregulation, improved memory consolidation, attention, & working memory in controlled studies.

Stroke recovery / neuroprotection

Most Effective

Approved for ischemic stroke treatment in Russia. Reduces neurological deficit in post-stroke patients. Neuroprotective mechanism via BDNF & NGF.

Anxiety & depression

Moderate

Serotonergic & dopaminergic modulation produces mood-stabilizing effects. Less potent than Selank for pure anxiety.

Research Protocols

Cognitive enhancement

3–4 weeks, then 1–2 weeks off

Dose

300–600 mcg intranasal

Frequency

Once or twice daily, AM (and midday if 2x)

Route

Intranasal

Stroke recovery support

4–8 weeks under physician supervision

Dose

300 mcg SubQ

Frequency

Twice daily

Route

SubQ

Peptide Interactions

SelankSynergistic

The classic nootropic combo: Semax (cognitive stimulation, BDNF) + Selank (anxiolytic, focus). Often taken together at separate times of day.

Side Effects & Safety

Common

Nasal irritation (intranasal)
Mild stimulation or restlessness at higher doses
Vivid dreams

Uncommon

Headache
Irritability

When to Stop

Signs of allergic reaction
Active seizure disorder (theoretical concern)

How to Reconstitute

Reconstitute with 1 mL BAC water per 5–10 mg vial.

Transfer to nasal spray for intranasal use.

Refrigerate.

Dosing math: 1 mL BAC water per 5 mg = 5000 mcg/mL. For 300 mcg: 0.06 mL.

Quality Indicators

Good — use as normal

Clear, colorless solution

Acceptable

Very slight tint

Discard immediately

Cloudiness
Particulate

What to Expect

Day 1–5

Mental clarity & focus improve noticeably within the first few doses. Stimulating effect is mild.

Week 2–4

BDNF upregulation accumulating. Memory & learning improvements more pronounced.

Community Insights

Self-reported. Reflects user experience, not clinical outcomes.

Research References

Semax as a neuroprotective drug for ischemic stroke treatment

European Neuropsychopharmacology · 2001

Clinical trial showing statistically significant reduction in neurological deficit score in acute ischemic stroke patients treated with Semax nasal drops.

Verify what you have

Information on this page applies to pharmaceutical-grade peptides. Purity & identity of research-grade products vary. Certipep provides independent ESI-TOF-MS & HPLC analysis with a signed analytical report.

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